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M365 Enterprise Architect

Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

M365 Enterprise Architect will be responsible for M365 services, including administration, projects, and support activities for Arrowhead’s Digital Workplace team.  Key activities include delivering on the team’s project backlog and roadmap, optimizing, and supporting Microsoft 365 (M365) services, with a focus on Power Platform, Microsoft Teams, and SharePoint. This role involves analyzing business requirements, designing solutions that are cost effective, ensuring security and compliance, and providing technical support to enhance productivity and collaboration across the organization.  The role will report to the Sr. M365 Enterprise Architect and may be responsible for the work of consultants too.

Responsibilities

  •  SharePoint Administration & Development
    •  Design, configure, and maintain cost effective SharePoint Online sites, libraries, and lists.
    • Develop custom solutions with a positive ROI using SharePoint Framework (SPFx) and Power Apps.
    • Manage permissions, metadata, and content types to ensure efficient document management.
    •  Manage site migrations
  • Power Platform Administration & Development
    • Power Automate: Develop business process automations, workflows, and integrations with positive ROI.
    •  Power BI: Design and develop reports and dashboards.
    • Administer Power Platform environments, including governance, security, and user access.
    • Power Apps: Develop and manage custom business applications that are cost effective.
    • Dynamics 365 Finance and Operations tools and apps.
  • Azure Administration:
    • Cloud PaaS and IaaS experience.
    • Application administration.
    • Azure Integration Services and Dynamics F&O integration.
    • Experience with Azure Data Lake, Synapse Link, Fabric is preferred.
    •  Azure DevOps for backlog management and version control.
  • Microsoft Teams Administration
    • Configure and manage Teams settings, policies, and integrations.
    • Support end-users in adopting Teams for communication and collaboration.
    • Troubleshoot Teams-related issues, including voice, video, and app integrations.
  • Business Analysis & Solution Design
    • Collaborate with stakeholders/business partners to gather and analyze business requirements.
    • Design and implement solutions to address business needs in a cost-effective manner.
    • Provide recommendations for optimizing M365 tools and processes.
  • Support & Training:
    • Technical support for M365 services and resolve escalated issues.
    • Conduct user training sessions and create documentation to drive adoption.
    • Stay updated on M365 features and updates to recommend best practices.
  • Security & Compliance:
    • Ensure M365 configurations align with organizational security policies and compliance requirements.

Requirements:

  • 10+ years of experience with SharePoint. Must have deep experience with SharePoint Online
  • 5+ years of experience in Microsoft 365 administration and support.
  • 5+ years of experience with Office 365, the Power platform. Specifically with Power BI, Power Automate, Power Apps, Microsoft Forms
  • Working knowledge of Agile principles
  • Strong problem-solving skills and ability to work independently or in a team.
  • Excellent communication skills to interact with technical and non-technical stakeholders and business partners.
  • Bachelor’s degree in Computer Science, Information Technology, or related field (or equivalent experience).

Preferred Certifications

  • SharePoint
  • Teams
  • Power Platform

 

California pay range
$140,000$190,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

California Applicant Privacy Policy

Average salary estimate

$165000 / YEARLY (est.)
min
max
$140000K
$190000K

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Arrowhead Pharmaceuticals discovers and develops medicines that treat intractable diseases by silencing the genes that cause them. Our employees are nimble, science-driven, innovative professionals. In just the past six years, 12 of the medicines...

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Full-time, onsite
DATE POSTED
June 7, 2025

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