Senior Scientist (DMPK) (South San Francisco, San Diego, Cambridge, MA)

Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) is an innovative, research-based, commercial-stage biopharmaceutical company based in China and the United States focused on bringing transformative medicines for oncology, autoimmune disorders, infectious diseases, and neurological disorders to patients in China and around the world. Our goal is to leverage our competencies and resources to positively impact human health worldwide.

Founded in 2014, our experienced team has secured partnerships with leading global biopharmaceutical  companies, generating a broad and late-stage pipeline of innovative drug candidates. Based on our proven  track record of  success, Zai Lab has earned the reputation as a trusted partner of choice for global biopharmaceutical companies seeking to not only access the Chinese market but also find a long-term strategic partner for global clinical development.  Our unique business model builds on our in-licensed assets and innovative partnerships to expand our internal discovery and development capabilities and has created a portfolio of potential best-in-class and/or first-in-class therapies. Zai currently has four products on the market in China

Zai Lab was successfully listed on the Nasdaq Stock Market in September 2017 and completed secondary listing on Hong Kong Stock Exchange in September 2020. In 2022, Zai Lab became dual-primary listed on both the Nasdaq and the Hong Kong Stock Exchanges. Since its inception, Zai Lab has expanded significantly with several offices across China. In 2021, Zai Lab established its U.S. Headquarters in Cambridge, Massachusetts.  As of January 2022, the Company has a global team of approximately 2000 employees.

This hybrid role can be based in any of our locations: South San Francisco, San Diego, or Cambridge, MA.

The Senior Scientist is the subject matter expert in Drug Metabolism and Pharmacokinetics and will support several research programs in the company.

• Design in vivo pharmacokinetic studies in preclinical species, write and review study protocols.
• Coordinate and collaborate with CROs and internal cross-functions to request quotes, supply materials for studies, provide scientific input, and monitor study activities.
• Provide problem solving in the development of bioanalytical methods and the analysis of samples for large molecules.
• Analyze pharmacokinetic data with Phoenix.
• Interpret pharmacokinetic/pharmacodynamic (PK/PD) data in support discovery/development projects.
• Communicate and present PK results to cross-functional program teams.
• Participate in discovery/development project teams.
• Contribute to the preparation and review of study reports and documents for regulatory submissions.

REQUIRED

• PhD degree with four years of relevant industry experience; or equivalent combination of education, training and experience.
• Proficiency in reading and writing in both Chinese and English.

PREFERRED

• Good understanding of PK and ADME concepts.
• Hands-on experience in, but not limited to, pharmacokinetics.
• Ability to use Phoenix and other data management software.
• Experience in PK/PD analysis, design, interpretation, simulation.
• Hands-on experience in the development of bioanalytical methods in support of preclinical PK studies for large molecules.
• Excellent oral and written communication skills.
• Excellent interpersonal skills and ability to work in a team environment.
• A strong fit with Zai Lab’s culture and core values of commitment to excellence, patient-centered care, and collaboration. Must be resourceful, self-driven, and enthusiastic, with the ability to thrive in a dynamic start-up environment.
• Must have the highest personal values and ethical standards.

The pay range for this position at commencement of employment is expected to be between $160K and $180K/year. Base pay offered may vary depending on multiple individualized factors, including location, job-related knowledge, skills, education and experience. The total compensation package for this position may also include other elements, including corporate bonus and equity awards.  In addition Zai Lab offers a robust benefits package which includes comprehensive health insurance, 401(k) with company match, family advocacy programs, and various paid time off benefits, such as vacation, sick time, and parental leave. Details of participation in these benefit plans will be provided if an employee receives an offer of employment.

If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary as well as any other discretionary payment and benefits at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

At Zai, we are proud of the gender diversity of our company and our promotion of women in biotech. We have achieved gender base pay equity at all levels, 58% of our employees are women and 54% of our management positions are held by women. We are committed to the health of patients and our planet. That’s why our environmental protection, social responsibility, and corporate governance strategy, called “Trust for Life” is integrated within our business.

Disclaimer: This description is not intended to be construed as an exhaustive list of duties, responsibilities, or requirement for the position. All personnel may be required to perform duties outside of their normal responsibilities from time to time, as needed.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or based on disability.

Zai Lab is committed to protecting the privacy and security of the information we collect and to being transparent about the purposes for which we use your information. We have a Privacy Notice which sets forth our policies and practices for handling the information we collect and use in the employment context.  Privacy Notice available upon request.