Head of In Vivo Pharmacology - Oligonucleotide Sciences

Job Title: Director/Senior Director, In Vivo Pharmacology - Oligonucleotide Sciences

Location: 200 Cambridge Park Drive, Cambridge, MA

Position Overview: GSK is seeking an experienced Director or Senior Director of In Vivo Pharmacology to join our Oligonucleotide Sciences research team. This leadership role offers an exciting opportunity to drive the design and execution of in vivo strategies for multiple discovery and platform projects. The successful candidate will report to the Head of Oligonucleotide Sciences, interface across the organization, and may have the opportunity to build and lead a small team.

Key Responsibilities:

• Act as the single point of accountability for the design and execution of in vivo pharmacology strategies for all discovery and platform capability projects within the Oligonucleotide Sciences team.
• Interface with cross-functional teams, including in vitro biology, chemistry, informatics, biostatistics, disease biology, DMPK and non-clinical safety, to design effective and robust PK/PD studies in line with project requirements.
• Build and maintain effective relationships with leading CROs, ensuring timely delivery of high-quality study data.
• Work with rodent (including transgenics where appropriate) and non-human primate (NHP) models to generate high-quality data supporting project goals while adhering to GSK’s study design, data integrity, and animal welfare policies.
• Analyze, interpret, and present data to internal stakeholders, ensuring clear communication of study outcomes and recommendations.
• Remain current with scientific and technological advancements in the field of oligonucleotide therapeutics and in vivo pharmacology.
• Potentially build and lead a small team of in vivo pharmacologists to support expanding research needs.

Minimum Qualifications:

• PhD in Pharmacology, Biology, or a related field.
• At least 10 years of experience in the design and execution of in vivo PK/PD studies.
• Experience in the field of oligonucleotide therapeutics, including contemporary routes of administration such as subcutaneous, inhaled, and intrathecal.
• Ability to work independently and manage multiple projects simultaneously.
• Ability to collaborate with multidisciplinary teams, including in vitro biology, chemistry, biostatistics, and non-clinical safety.
• Demonstrable leadership capabilities with experience working in a complex matrix environment.
• Demonstrable analytical, problem-solving, and communication skills.
• Experience working with rodent and non-human primate (NHP) models.
• Ability and excitement to contribute to the development and success of a new and growing department.

Preferred Qualifications:

• Experience working in a pharmaceutical or biotechnology research environment.
• Record of high-impact publication in peer reviewed journals.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/