Principal Research Scientist I - Solid State Chemistry

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state-of-the-art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.

Solid State Chemists within AbbVie's MPDD function work in cross-functional teams to support projects through all phases of development (Lead Optimization to Process Validation). In early development, they work in cross functional teams to help pick the best molecule for development, identify solid form of the API and develop scalable API isolation processes for early clinical studies. During Phase II, they work with engineers and formulation scientists to establish structure-property-performance correlations and deliver commercial API isolation processes with optimized physical properties. In the final stages of development, Solid State Chemists at AbbVie help align control strategies across API and drug product and transition isolation processes and relevant physical characterization methods to commercial manufacturing sites. Throughout development, they work with relevant teams to ensure successful regulatory submissions. In order to develop and implement robust solutions, Solid State Chemists at AbbVie use a very diverse set of experimental, analytical techniques, automation and modeling tools. In this role, you will be a key leader within dynamic, engaging, and multidisciplinary project teams with the ability to apply your skills and expertise in this exciting function with diverse accountabilities across development phases.

AbbVie's MPDD organization is seeking a highly motivated and experienced leader with expertise in the areas of solid form development and pharmaceutical materials science, for a Principal Research Scientist I position.

Minimum Qualifications

• Bachelor’s Degree & 14+ years of experience OR Master’s degree & 12+ years of experience OR PhD & 6+ years of experience. Candidates with less experience may be considered for other opportunities.
• Strong knowledge of solid form development, design and control of associated unit operations along with expertise in analytical tools used therein demonstrated through multiple projects.

Preferred Qualifications:

• Experience in the CMC development of oral peptide is highly desirable.
• Experience in solid-form screening, physical properties characterization, and crystallization development of oral peptide, nucleic acid, and therapeutic protein are highly desirable.
• A comprehensive understanding of strategies and technologies for peptide and protein crystallization is highly desirable.
• Preferred educational background includes but is not restricted to Biopharmaceutical Sciences, Physical Chemistry, Chemical Biology, Material Sciences, Chemical Engineering or Biomedical Engineering.

Other Required Competencies:

• Proven competence in representing the department within cross-functional project teams and expertise centers, with proficiency in developing and implementing strategies that align with functional goals and key scientific objectives.
• Demonstration of creative, "out-of-the-box" thinking to address complex technical challenges and promote new technologies in a fast-paced environment, with expertise in identifying emerging scientific trends and integrating them into strategic plans.
• Possesses a strong record of independently leading research to achieve both short- and long-term organizational goals, while effectively leveraging external innovations and resources to enhance internal capabilities.
• Excellent communication skills with a demonstrated record of building lasting partnerships across organizational boundaries.
• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence”, and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

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• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

• This job is eligible to participate in our short-term incentive programs. ​​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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