Principal Research Scientist I, Discovery Biotherapeutics – T-cell Engager Multispecifics Group Lead

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

The Multispecifics Engineering group at AbbVie is seeking a highly skilled and self-motivated scientist to join a dynamic team supporting Discovery Biotherapeutics and lead a team focused on T-cell engagers. This position will impact projects through engineering, production, and characterization of multispecific biopharmaceutical products. The ideal candidate should have extensive experience with biologics and multispecifics production platforms, analytical characterization, and a proven track record implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs. The ideal candidate will also have people and project management experience. The applicant should be an enthusiastic, creative scientist who will make tangible contributions to the pipeline.

Key Responsibilities:

• Responsible for design, engineering, and production of multispecific biologics, primarily to support Oncology projects
• Serve as a Multispecifics Engineering representative in cross-functional teams with Oncology, Discovery Biotherapeutics, and Development Sciences, providing project updates, analysis, and advice; recognized expert in multispecific design and production
• Serve as the Biologics Lead on projects to coordinate activities and transitions from hit generation through candidate nomination
• Supervise a team of scientists, evaluate team performance, and be accountable for the effective performance of the team
• Identify and solve technical problems independently, conceive and implement innovative research ideas
• Ensure consistency and quality of technical reports
• Present original work internally across departments and at internal and external scientific conferences; may author or co-author peer-reviewed scientific papers or patents

Minimum Qualifications:

• BS, MS, or PhD in Biochemistry, Biochemical engineering or related discipline with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of experience in bi- and trispecific engineering or T-cell engagers
• Experience with protein, biologics, fragments, or multispecifics (e.g. bispecifics, trispecifics, bispecific protein fusions) design, expression and purification
• Experience managing direct reports and providing performance evaluations and development opportunities
• Excellent organizational skills and the ability to manage multiple projects simultaneously
• Team player with the ability to operate in a fast-paced multi-disciplinary environment
• Candidate must be a goal-oriented team player with excellent verbal and written communication skills and strong can-do attitude

Preferred Qualifications:

• Experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
• Experience with mass spectrometry analysis and software (Protein Metrics)
• Experience with CRO coordination for production
• Expert understanding of current state of protein expression/separation/analytical technologies
• Ability to explore and develop new approaches to further advance innovative purification and screening technologies for multispecifics
• Extensive knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
• Bi- and tri-specific design to support T-cell redirection and Oncology projects
• Recognized in the scientific community through a sustained record of peer-reviewed publications and patents preferred

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. ​

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

• This job is eligible to participate in our short-term incentive programs. ​

• This job is eligible to participate in our long-term incentive programs​

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled. 

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